2. NF-κB Stem Cell/Wnt Immunology/Inflammation
  3. Wnt RANKL/RANK Toll-like Receptor (TLR) β-catenin
  4. Pamidronate (disodium) (Standard)

Pamidronate (disodium) (Standard)  (Synonyms: 帕米膦酸二钠 (Standard))

目录号: HY-B0012AR 纯度: ≥98%
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Pamidronate disodium (Standard) 是 Pamidronate disodium 的分析标准品。Pamidronate disodium (Standard)，第二代含氮双膦酸盐，是骨丢失抑制剂。Pamidronate disodium (Standard) 通过上调软骨和软骨下骨中 OPG 的表达、并抑制 RANKL 和 MMP-9 在软骨和软骨下骨以及 TLR-4 在软骨中的表达来显著抑制早期骨关节炎的软骨下骨丢失，从而缓解软骨退变。此外 Pamidronate disodium (Standard) 还可以抑制 Wnt 和 β-catenin 的信号传导，能用于骨质酥松症和骨肉瘤的研究。

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Pamidronate (disodium) (Standard) Chemical Structure

Pamidronate (disodium) (Standard) Chemical Structure

CAS No. : 57248-88-1

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生物活性

Pamidronate disodium (Standard) is the analytical standard of Pamidronate disodium.Pamidronate disodium (Standard), the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium (Standard) significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium (Standard) can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma.

分子量

279.03

Formula

C3H9NNa2O7P2
CAS 号
中文名称

帕米膦酸二钠 (Standard)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Pamidronate (disodium) (Standard) 相关分类

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Keywords:

Pamidronate (disodium) (Standard)57248-88-1帕米膦酸二钠 (Standard)WntRANKL/RANKToll-like Receptor (TLR)β-cateninBeta cateninosteoarthritis (OA)osteosarcomaosteoporosisInhibitorinhibitorinhibit

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