2. Anti-infection
  3. Bacterial
  4. Panobacumab

Panobacumab  (Synonyms: 帕巴库单抗; KBPA101)

目录号: HY-P99214 纯度: 98.24%
COA

摩尔计算器

Panobacumab (KBPA101) 是一种完全人 IgM/κ 单克隆抗体，由人类B淋巴细胞产生，对血清型 O11 P. aeruginosa 的 LPS O 多糖具有抗性。

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CAS No. : 885053-97-4

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Panobacumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Panobacumab (KBPA101) is a fully human IgM/κ monoclonal antibody generated by immortalizing human B lymphocytes against the LPS O polysaccharide of serotype O11 of P. aeruginosa[1].

同型

IgM kappa
种属

Human
体外研究
(In Vitro)

Panobacumab (KBPA101) strongly binds to 18 of 20 clinical O11 isolates, functional avidity of KBPA101 to O11 LPS determined by inhibition ELISA is 5.81×107 M-1± 2.8×107 M-1[1].
Panobacumab (KBPA101) (0.0001-100 ng/mL; 2 h) specifically mediates complement-dependent opsonophagocytosis of P. aeruginosa serotype O11 with an IC50 of 0.16 ng/mL[1].
Panobacumab (KBPA101) (0.1-10 ng/mL) shows direct complement-dependent killing of P. aeruginosa serotype O11 cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Panobacumab 相关抗体:
体内研究
(In Vivo)

Panobacumab (KBPA101) (1-4 mg/kg; i.v.; once) protects mice from systemic infection with P. aeruginosa serotype O11 in a murine burn wound model[1].
Panobacumab (KBPA101) (0.005-0.4 mg/kg; i.v.; once) protects mice from local lung infection with P. aeruginosa serotype O11 in an acute lung infection model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NMRI mice, murine burn wound model[1]
Dosage: 1, 2, or 4 mg/kg
Administration: Intravenous injection, single dose
Result: Significantly reduced mortality compared to untreated control animals administered either immediately or 4 h postchallenge.
Animal Model: BALB/c mice, acute lung infection model[1]
Dosage: 0.005 to 0.4 mg/kg
Administration: Intravenous injection, single dose
Result: Led to rapid clearance of P. aeruginosa from the lung, completely cleared systemic P. aeruginosa from the spleen, whereas live bacteria were still present in untreated mice at 48 h postchallenge, showed milder macroscopic lung pathology at 6 and 24 h after infection.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

帕巴库单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgM-kappa
纯度 & 产品资料
参考文献

Panobacumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Panobacumab885053-97-4KBPA101帕巴库单抗KBPA 101KBPA-101BacterialP. aeruginosaB lymphocytesLPS O polysaccharideserotype O11Inhibitorinhibitorinhibit

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