2. Cell Cycle/DNA Damage Epigenetics Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. PARP Reactive Oxygen Species Apoptosis
  4. PARP1-IN-27

PARP1-IN-27 (Compound 9B) 是 PARP1 和 PARP2 的抑制剂，在细胞 SUM149PT 中的 IC50 分别为 2.53 nM 和 6.45 nM。PARP1-IN-27 抑制 BRCA 突变癌细胞 SUM149PT，HCC1937 和 Capan-1 的增殖，IC50 分别为 0.62，1.91 和 4.26 μM。PARP1-IN-27 加剧 DNA 双链断裂，增加 ROS 生成，在 G2/M 期阻滞细胞周期，并在 SUM149PT 中诱导细胞凋亡 (apoptosis)。

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PARP1-IN-27 Chemical Structure

PARP1-IN-27 Chemical Structure

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PARP1-IN-27 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PARP1-IN-27 (Compound 9B) is the inhibitor for PARP1 and PARP2, with IC50 of 2.53 nM and 6.45 nM in cell SUM149PT. PARP1-IN-27 inhibits the proliferation of BRCA-mutated cancer cells SUM149PT, HCC1937 and Capan-1, with IC50 of 0.62, 1.91 and 4.26 μM respectively. PARP1-IN-27 aggravates DNA double-strand breaks, increases ROS generation, arrests cell cycle at G2/M phase, and induces apoptosis in SUM149PT[1].

分子量

313.28

Formula

C17H12FNO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PARP1-IN-27 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP1-IN-27PARPReactive Oxygen SpeciesApoptosispoly ADP ribose polymerase SUM149PTHCC1937Capan-1Inhibitorinhibitorinhibit

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