2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Pellotine

Pellotine 是一种生物碱，可从Lophophora中分离得到。Pellotine 是 5-HT7 受体 (5-HT7 receptor) 的反向激动剂，EC50 为 291 nM。Pellotine 对 5-HT1DR 和 5-HT6R 具有良好的亲和力，Ki 分别为 117 nM 和 170 nM。Pellotine 可降低细胞内 cAMP 水平，从而降低神经元兴奋性和神经递质释放。

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Pellotine Chemical Structure

Pellotine Chemical Structure

CAS No. : 19622-05-0

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Pellotine 相关抗体

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查看 5-HT Receptor 亚型特异性产品:

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5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pellotine is an alkaloid that can be isolated from Lophophora. Pellotine is the inverse agonist for 5-HT7 receptor with an EC50 of 291 nM. Pellotine exhibits good affinity to 5-HT1DR and 5-HT6R with Ki of 117 nM and 170 nM. Pellotine reduces intracellular cAMP levels, thereby reducing neuronal excitability and neurotransmitter release[1].

IC50 & Target

Human 5-HT7 Receptor

291 nM (EC50)

5-HT1D Receptor

117 nM (Ki)

5-HT6 Receptor

170 nM (Ki)

分子量

237.29

Formula

C13H19NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pellotine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pellotine19622-05-05-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorinverse agonistneuronal excitabilityInhibitorinhibitorinhibit

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