2. Neuronal Signaling
  3. Amyloid-β
  4. Pep63

Pep63 是一种神经保护肽 (VFQVRARTVA)。Pep63 对突触可塑性和记忆具有神经保护作用。Pep63 可以与 Aβ1-42 寡聚体竞争性结合，可阻断 Aβ 纤维形成。Pep63 可用于阿尔茨海默病 (AD) 研究。

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Pep63 Chemical Structure

Pep63 Chemical Structure

CAS No. : 1781242-18-9

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Pep63 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pep63 is a neuroprotective peptide (VFQVRARTVA). Pep63 has a neuroprotective effect on synaptic plasticity and memory. Pep63 can competitively bind with Aβ1-42 oligomers, and can block Aβ fiber formation. Pep63 can be used for Alzheimer’s disease (AD) research[1].

体内研究
(In Vivo)

Pep63 可通过立体定向给药至背部海马，有效阻断 EphB2-ADDLs (Aβ 衍生的可扩散配体)的相互作用，并逆转早期 AD 小鼠模型中的记忆障碍[1]。
转铁蛋白脂质体 (Transferrin-liposome) 是一种载体，可通过转铁蛋白受体 (TfR) 介导的转胞吞作用将 Pep63 递送至大脑[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1146.34

Formula

C51H87N17O13
CAS 号
Sequence

Val-Phe-Gln-Val-Arg-Ala-Arg-Thr-Val-Ala
Sequence Shortening

VFQVRARTVA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pep63 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pep631781242-18-9Pep 63Pep-63Amyloid-ββ-amyloid peptideAβAbetaTransferrin-Pep63-liposomeEphB2Aβ1-42oligomerneuroprotectiveAlzheimer’s diseaseInhibitorinhibitorinhibit

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