2. Cell Cycle/DNA Damage
  3. PERK
  4. PERK/eIF2α activator 1

PERK/eIF2α activator 1 (compound V8) 是一种具有抗肿瘤活性的黄酮类化合物。PERK/eIF2α activator 1 诱导细胞凋亡并激活 PERK-eIF2α-ATF4 通路。PERK/eIF2α activator 1 抑制 HepG2 细胞增殖，IC50 值为 23 μM。

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PERK/eIF2α activator 1 Chemical Structure

PERK/eIF2α activator 1 Chemical Structure

CAS No. : 1178583-17-9

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PERK/eIF2α activator 1 相关抗体

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  • 生物活性

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生物活性

PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC50 value of 23 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
1.26 μM
Compound: 3b
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28117202]
HepG2 IC50
2.64 μM
Compound: 3b
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28117202]
分子量

443.49

Formula

C24H29NO7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PERK/eIF2α activator 1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PERK/eIF2α activator 11178583-17-9PERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseFlavonoidanti-tumorInhibitorinhibitorinhibit

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