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  4. PF-07059013

PF-07059013 是一种口服有效的镰状血红蛋白 (HbS) 非共价调节剂。PF-07059013 以纳摩尔亲和力特异性结合 Hb，并表现出强烈的红细胞 (RBCs) 分裂。PF-07059013 可用于镰状细胞病 (SCD) 研究。

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PF-07059013 Chemical Structure

PF-07059013 Chemical Structure

CAS No. : 2435610-93-6

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PF-07059013 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research[1][2].

体内研究
(In Vivo)

PF-07059013 (10-490 mg/kg，口服灌胃，每日2次，连用2周) 显示 Townes SCD 小鼠的镰刀减少[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Townes SCD mice (8-10 weeks old, male)[1]
Dosage: 10, 40, 200, and 490 mg/kg
Administration: Oral gavage, twice daily, for 2 weeks
Result: Showed a 37.8% (±9.0%) reduction in sickling at 200 mg/kg compared to vehicle treated mice.
Clinical Trial
分子量

365.36

Formula

C19H16FN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-07059013 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-070590132435610-93-6PF07059013PF 07059013OthersSickle cell diseasesickled hemoglobinInhibitorinhibitorinhibit

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目录号：
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