Phenylpyropene C  (Synonyms: S14-95)

Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC₅₀=5.4~10.8 μM). Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC₅₀ of 16.0 μM^[1][2].

Phenylpyropene C (0.1-1000 μM) inhibits ACAT activity with the IC₅₀ of 16.0 μM in a dose dependent fashion^[1].
Phenylpyropene C inhibits the IFN-γ mediated expression of the reporter gene with IC₅₀s of 5.4 μM to approximately 10.8 μM^[2].
Phenylpyropene C inhibits the expression of the proinflammatory enzymes COX-2 and NOS II at 10.8 μM in LPS/IFN-γ stimulated J774 mouse macrophages^[2].
Phenylpyropene C inhibits the activation of the p38 MAP kinase, which is involved in the inducible expression of many proinflammatory genes^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

450.57

C₂₈H₃₄O₅

419532-92-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rho MC, et, al. Phenylpyropene C, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Penicillium griseofulvum F1959. J Antibiot (Tokyo). 2002 Feb;55(2):211-4.  [Content Brief]

  [2]. Erkel G, et, al. S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species. J Antibiot (Tokyo). 2003 Apr;56(4):337-43.  [Content Brief]