2. Metabolic Enzyme/Protease
  3. MMP Angiotensin-converting Enzyme (ACE) Neprilysin Endogenous Metabolite
  4. Phosphoramidon

Phosphoramidon  (Synonyms: 磷酰胺)

目录号: HY-N2021
产品使用指南

摩尔计算器

Phosphoramidon，一种微生物代谢物 (microbial metabolite)，是一种特异性金属蛋白酶嗜热菌蛋白酶 (metalloprotease thermolysin) 抑制剂，其IC50 为0.4 μg/mL。Phosphoramidon 也抑制内皮素转换酶 (ECE)、中性肽酶 (NEP) 和血管紧张素转换酶 (ACE)，IC50 分别为 3.5、0.034 和 78 μM。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Phosphoramidon Disodium 通常具有更好的水溶性和稳定性。

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Phosphoramidon Chemical Structure

Phosphoramidon Chemical Structure

CAS No. : 36357-77-4

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Customer Review

Other Forms of Phosphoramidon:

Phosphoramidon 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively[1][2][3].

IC50 & Target[1]

Microbial Metabolite

 

体外研究
(In Vitro)

Phosphoramidon (1-500 μM; 30 min) inhibits ET-converting enzyme (ECE) activity in a dose-dependent manner in solubilized rabbit lung membranes[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Phosphoramidon 相关抗体:
体内研究
(In Vivo)

Phosphoramidon (0.25 mg/kg per min; i.v.) suppresses the hypertensive effect of big endothelin-1 in rats[4].
Phosphoramidon (1-30 mg/kg; i.v.; once) blocks the pressor activity of porcine big endothelin-1-(1-39) in rats[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[4]
Dosage: 0.25 mg/kg per min
Administration: Intravenous injection
Result: Markedly suppressed the hypertensive effect of big endothelin-1.
分子量

543.50

Formula

C23H34N3O10P
CAS 号
中文名称

磷酰胺
结构分类
初始来源

Streptomyces tanashiensis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Phosphoramidon 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phosphoramidon36357-77-4磷酰胺MMPAngiotensin-converting Enzyme (ACE)NeprilysinEndogenous MetaboliteMatrix metalloproteinasesNeutral endopeptidaseNEPCluster of differentiation 10CD10thermolysinSD ratendothelin-1ECEendothelin-converting enzymeneutral endopeptidaseInhibitorinhibitorinhibit

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