PKI(5-24) TFA 

PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor^[1][2].

PKI(5-24) TFA is a 20-residue peptide has been synthesized that corresponds to the active site of the skeletal muscle inhibitor protein^[1].
PKI(5-24) TFA inhibits phosphotransferase activity of the mutant cGMP kinase with higher potency than that of wild type, with Ki values of 42 μΜ and 160 μΜ, respectively^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2336.40

C₉₄H₁₄₈N₃₂O₃₁.C₂HF₃O₂

Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp

TTYADFIASGRTGRRNAIHD

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cheng HC, et al. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem. 1986;261(3):989-992.  [Content Brief]

  [2]. Ruth P, et al F. A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5-24). Biol Chem. 1996;377(7-8):513-520.  [Content Brief]