2. Metabolic Enzyme/Protease
  3. TrxR
  4. PMX464

PMX464 (AW 464) 是一种硫醇反应性喹啉，是硫氧还蛋白-硫氧还蛋白还原酶 (Trx/TrxR) 系统的抑制剂。PMX464 可抑制 NF-κB 介导的人 II 型肺泡上皮细胞促炎激活。PMX464 可用于癌症研究。

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PMX464 Chemical Structure

PMX464 Chemical Structure

CAS No. : 485842-97-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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PMX464 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.5 μM
Compound: 1
Growth inhibition of human A549 cells after 72 hrs by MTT assay
Growth inhibition of human A549 cells after 72 hrs by MTT assay
[PMID: 17343370]
HCT-116 IC50
0.03 μM
Compound: 1
Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
[PMID: 17343370]
HCT-116 GI50
0.11 μM
Compound: PMX 464
Antitumor activity against human HCT116 cells by MTT assay
Antitumor activity against human HCT116 cells by MTT assay
[PMID: 16908135]
HT-29 GI50
0.59 μM
Compound: PMX 464
Antitumor activity against human HT29 cells by MTT assay
Antitumor activity against human HT29 cells by MTT assay
[PMID: 16908135]
MCF7 GI50
0.44 μM
Compound: PMX 464
Antitumor activity against human MCF7 cells by MTT assay
Antitumor activity against human MCF7 cells by MTT assay
[PMID: 16908135]
MDA-MB-468 GI50
0.41 μM
Compound: PMX 464
Antitumor activity against human MDA-MB-468 cells by MTT assay
Antitumor activity against human MDA-MB-468 cells by MTT assay
[PMID: 16908135]
MRC5 EC50
0.18 μM
Compound: 4, PMX 464
Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay
Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay
[PMID: 22264753]
分子量

243.28

Formula

C13H9NO2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PMX464 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PMX464485842-97-5AW 464PMX 464PMX-464AW464AW-464TrxRThioredoxin Reductasethioredoxin-thioredoxin reductaseTrx/TrxRNF-κBInhibitorinhibitorinhibit

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目录号：
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