PNC-27 

PNC-27, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 is an anticancer peptide. PNC-27 can be used in acute myeloid leukemia research^[1][2][3].

PNC-27 (50 μg/mL；0-3 小时) 诱导癌细胞死亡^[1]。
PNC-27 (50 μg/mL；15 分钟) 与 A2058 和 MCF-7 细胞中细胞膜结合的 HDM-2 结合^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PNC-27 (腹腔注射；40 mg/kg；每天；2-3 周) 在小鼠中显示出抗白血病活性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4031.73

C₁₈₈H₂₉₃N₅₃O₄₄S

1159861-00-3

PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sarafraz-Yazdi E, et al. Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1918-23.  [Content Brief]

  [2]. Wang H, et al. Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia. Leukemia. 2020 Jan;34(1):75-86.  [Content Brief]

  [3]. Ehsan Sarafraz-Yazdi, et al. PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines. 2022 Apr 20;10(5):945.  [Content Brief]