2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. PNU109291

PNU109291 是一种有效的选择性 5-HT1D 激动剂。PNU109291 减少三叉神经节刺激引起的硬脑膜血浆外渗。

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PNU109291 Chemical Structure

PNU109291 Chemical Structure

CAS No. : 187665-60-7

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PNU109291 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1].

体内研究
(In Vivo)

PNU109291 (0.24、2.4、7.3、24.4、73.3 nmol/kg；皮下注射) 减少猪的三叉神经节刺激引起的硬脑膜血浆外渗[1]。
PNU109291 (3 µM) 抑制大鼠弗氏佐剂 (CFA) 诱发的 EPSC（兴奋性突触后电流），但不抑制注射盐水的处理组[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 200-500g, male Hartley guinea pigs[1]
Dosage: 0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg
Administration: S.c.; 60 min before electrical stimulation
Result: Dose-dependently decreased plasma protein extravasation with an IC50 value of 4.2 nmol/kg.
分子量

409.52

Formula

C24H31N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PNU109291 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNU109291187665-60-7PNU 109291PNU-1092915-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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产品名称：
PNU109291
目录号：
HY-103132
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