2. Anti-infection
  3. Bacterial
  4. PqsR-IN-1

PqsR-IN-1 (Compound 18) 是一个有效的 PqsR 抑制剂。PqsR-IN-1 减少 pyocyanin 的产生，细胞毒性很低。

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PqsR-IN-1 Chemical Structure

PqsR-IN-1 Chemical Structure

CAS No. : 1333636-58-0

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PqsR-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PqsR-IN-1 (Compound 18) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity[1].

IC50 & Target

PqsR[1]
体外研究
(In Vitro)

PqsR-IN-1 (Compound 18) inhibits pqs system with IC50 values of 313 ± 156.2 nM and 342 ± 39.4 nM against two different PA strains PAO1-L and PA14, respectively[1].
PqsR-IN-1 significantly reduces pyocyanin production to 23% against a control of 0.1% DMSO at 3 × the IC50 value in P. aeruginosa strain PAO1-L[1].
PqsR-IN-1 (0-100 µM, 16 h) shows no significant toxicity to A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PqsR-IN-1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: A549 lung epithelial cells
Concentration: 0.1, 1, 12.5, 25, 50, and 100 µM
Incubation Time: 16 h
Result: Showed no significant toxicity.
分子量

347.86

Formula

C17H18ClN3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PqsR-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PqsR-IN-11333636-58-0BacterialLow cytotoxicityPyocyaninPAO1-LPA14Inhibitorinhibitorinhibit

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目录号：
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