2. Others
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  4. PR280

PR280 是一种强效的二氢神经酰胺脱饱和酶1 (Des1) 抑制剂 (IC50=700 nM)。PR280 与 Des1 的氨基酸残基形成氢键，同时其环丙烯酮基团可能与铁中心形成配位，从而稳定了与 Des1 活性位点的结合，抑制二氢神经酰胺 (dhCer) 形成神经酰胺的鞘氨醇脂类合成途径。PR280 可用于鞘氨醇脂类代谢相关的疾病，如癌症和代谢性疾病的研究。

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PR280 Chemical Structure

PR280 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

PR280 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PR280 is a potent inhibitor of dihydroceramide desaturase 1 (Des1) (IC50=700 nM). PR280 forms hydrogen bonds with the amino acid residues of Des1, and its cyclopropenone group may form a coordination with the iron center, thus stabilizing the binding to the active site of Des1 and inhibiting the sphingosine lipid synthesis pathway of dihydroceramide (dhCer) to form ceramide. PR280 can be used in the study of diseases related to sphingosine lipid metabolism, such as cancer and metabolic diseases[1].

分子量

451.68

Formula

C27H49NO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PR280 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PR280PR 280PR-280OthersSphingosine lipidsCeramidesMetabolic DiseasesDes 1Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-163472
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