2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Proadrenomedullin (N-20) (bovine, porcine)

Proadrenomedullin (N-20) (bovine, porcine)  (Synonyms: ProADM N20(bovine, porcine); PAMP-20(bovine, porcine))

目录号: HY-P5876
产品使用指南

摩尔计算器

Proadrenomedullin (N-20) (ProADM N20) (bovine, porcine) 是一种从嗜铬细胞中释放的有效的非竞争性降压和儿茶酚胺释放 (catecholamine release) 抑制肽。Proadrenomedullin (N-20) (bovine, porcine) 抑制 PC12 嗜铬细胞瘤细胞儿茶酚胺分泌，其 IC50 为 350 nM。Proadrenomedullin (N-20) (bovine, porcine) 还能阻断烟碱能激动剂对茶酚胺释放的脱敏作用 (EC50≈270 nM)，以及烟碱信号转导 (22Na+摄取)。

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Custom Peptide Synthesis

Proadrenomedullin (N-20) (bovine, porcine) Chemical Structure

Proadrenomedullin (N-20) (bovine, porcine) Chemical Structure

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Proadrenomedullin (N-20) (bovine, porcine) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Proadrenomedullin (N-20) (ProADM N20) (bovine, porcine) is a potent and noncompetitive hypotensive and catecholamine release-inhibitory peptide released from chromaffin cells. Proadrenomedullin (N-20) (bovine, porcine) inhibits catecholamine secretion with an IC50 of 350 nM in PC12 pheochromocytoma cells. Proadrenomedullin (N-20) (bovine, porcine) also blocks (EC50≈270 nM) nicotinic cholinergic agonist desensitization of catecholamine release, as well as desensitization of nicotinic signal transduction (22Na+ uptake)[1].

IC50 & Target

IC50: 350 nM (catecholamine secretion)[1]
分子量

2444.84

Formula

C112H178N36O26
Sequence

Ala-Arg-Leu-Asp-Val-Ala-Ala-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2
Sequence Shortening

ARLDVAAEFRKKWNKWALSR-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Proadrenomedullin (N-20) (bovine, porcine) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Proadrenomedullin (N-20) (bovine, porcine)ProADM N20(bovine, porcine) PAMP-20(bovine, porcine)nAChRNicotinic acetylcholine receptorschromaffin cellPC12pheochromocytoma cellnicotinic signalingnoncompetitiveInhibitorinhibitorinhibit

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