2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Propanidid

Propanidid  (Synonyms: Sombrevin; Fabantol)

目录号: HY-116457
产品使用指南

摩尔计算器

Propanidid (Sombrevin; Fabantol) 是一种 γ-氨基丁酸 A 型受体 (GABAA receptor) 激动剂，也是一种短效的非巴比妥类全身活性剂，可抑制或缓解疼痛。Propanidid 可以降低动脉血压。

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Propanidid Chemical Structure

Propanidid Chemical Structure

CAS No. : 1421-14-3

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Propanidid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABAA) receptor agonist and a short-acting non-barbiturate general agent that can suppress or relieve pain. Propanidid can decrease the arterial pressure[1][2].

IC50 & Target

GABAA receptor[1]
体内研究
(In Vivo)

Propanidid (Sombrevin) (3-5 mg/kg; injected into the femoral vein; single dosage) changes the orientation tuning of 58 visual cortex neurons[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult cats (immobilized by D-tubocurarine)[3]
Dosage: 3-5 mg/kg
Administration: Injected into the femoral vein; single dosage
Result: A reliable change of the preferable orientation by 47.6 ± 5.6 degrees took place in 60% of 58 primary visual cortex neurons, while in the remaining cells it was stable in all stages of anaesthesia.
The width of the orientation tuning changed reliably by 65.2 ± 6.7 degrees on the average in 55% of neurons, while in 31% of neurons the tuning acuteness was worse, but in 24% it was sharper.
The preferable orientation, the width of the tuning and the frequency of the neuron discharge as a rule recovered in 30 min after the beginning of the anaesthesia.
分子量

337.41

Formula

C18H27NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Propanidid 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

Propanidid1421-14-3Sombrevin FabantolGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAAanestheticarterial pressureInhibitorinhibitorinhibit

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