2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Propargyl-Tos

Propargyl-Tos 是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联活性分子 (ADC)。Propargyl-Tos 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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Propargyl-Tos Chemical Structure

Propargyl-Tos Chemical Structure

CAS No. : 23418-85-1

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Propargyl-Tos 相关抗体

Top Publications Citing Use of Products

查看 ADC Linker 亚型特异性产品:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

Cleavable Linker

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Propargyl-Tos 相关抗体:
分子量

224.28

Formula

C11H12O3S
CAS 号
性状

液体（密度：1.27 g/cm3）

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 98.64%

COA (285 KB) HNMR (130 KB) GC (217 KB)

产品使用指南 (1538 KB)
参考文献

Propargyl-Tos 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-Tos23418-85-1ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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目录号：
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