2. Protein Tyrosine Kinase/RTK
  3. Bcr-Abl
  4. PROTAC BCR-ABL1 ligand 1

PROTAC BCR-ABL1 ligand 1，化合物 GMB-475， 是靶向蛋白水解的嵌合体 (PROTAC) 的配体，其以变构方式靶向 BCR-ABL1 蛋白并募集 E3 连接酶 Von Hippel-Lindau，从而导致泛素化和随后的 BCR-ABL1 蛋白的降解。

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PROTAC BCR-ABL1 ligand 1 Chemical Structure

PROTAC BCR-ABL1 ligand 1 Chemical Structure

CAS No. : 2489876-34-6

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PROTAC BCR-ABL1 ligand 1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC BCR-ABL1 ligand 1, compound GMB-475, is the ligand of PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of BCR-ABL1[1].

体外研究
(In Vitro)

GMB-475 (0-10 μM) exhibits cell proferation with IC50 values of 1.11,1.98,0.37 μM for BCR-ABL1 WT, T315I, G250E cells, respectively[1].
GMB-475 (0-30 μM) induces the degradation of BCR-ABL1 and c-ABL1 with concomitant inhibition of downstream signaling via the STAT5 pathway, in a dose- and time-dependent fashion in the context of both K562 and Ba/F3 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC BCR-ABL1 ligand 1 相关抗体:

Western Blot Analysis[1]

Cell Line: K562 and Ba/F3 cells
Concentration: 0-30 μM
Incubation Time:
Result: Decreased p-STAT5 expression.
分子量

347.29

Formula

C17H12F3N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC BCR-ABL1 ligand 1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

PROTAC BCR-ABL1 ligand 12489876-34-6Bcr-AblInhibitorinhibitorinhibit

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