2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Interferon & Receptors
  5. IFN-alpha
  6. IFN-alpha 14

IFN-alpha 14  (干扰素 α14)

重组蛋白定制服务

干扰素 α14 (IFNA10;IFN-α10) 属于 α / β 干扰素 (IFN) 家族，由巨噬细胞产生，具有抗病毒活性[1]。干扰素 (IFN) 最初被认为是一种“干扰”体外病毒复制的物质。IFN-α/β 及其相关分子被分为 I 型干扰素，其他干扰素则分为两种——II 型干扰素 (IFN-γ) 和 III 型干扰素 (IFN-λ)[2]。干扰素刺激两种酶的产生：一种蛋白激酶和一种低聚腺苷酸合成酶。干扰素 α (IFNa) 在各种癌症中显示出显著的生物活性，特别是血液系统恶性肿瘤，如毛细胞白血病和慢性骨髓性白血病[3]。干扰素 α14 参与 JAK/STAT 信号通路，被认为是减少 CTLA4 和 FOXP3 表达的有效调控因子。因此，调节性 T 细胞 (regulatory T cells, Tregs) 作为调节外周自反应 T 淋巴细胞的关键细胞，经过干扰素 α14 的调节而使功能状态不稳定[4]。干扰素 α14 是在未感染的小鼠组织中发现的一个新基因，被发现缺乏 N-糖基化，并在病毒感染时受诱导表达，这与 干扰素 α13 (IFN-alpha 13) 的特质相反[4]。

IFN-alpha 14 (IFNA14; IFN-α14), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities[1]. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively[2]. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia[3]. IFNα-14 involves in JAK/STAT signaling pathway, is identified as potent regulators that reduces both CTLA4 and FOXP3. Therefore, regulatory T cells (Tregs) as the key cells regulating peripheral autoreactive T lymphocytes, IFNα-14 regulates Treg functional states and destabilises Treg[4]. IFN-alpha14 is a new gene found in tissues of uninfected mice, also found to lack N-glycosylation and have its expression induced in response to viral infection in contrast to IFN-alpha 13[5].

目录号 产品名 / 同用名 种属 表达系统
目录号 产品名 作用方式 纯度
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z