2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Interferon & Receptors
  5. IFN-alpha
  6. IFN-alpha 4

IFN-alpha 4  (干扰素 α4)

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干扰素-α4 (IFNA4;IFN-α4) 属于 α/β 干扰素 (IFN) 家族，由巨噬细胞产生，具有抗病毒活性。干扰素 (IFN) 最初被认为是一种“干扰”体外病毒复制的物质。IFN-α/β 及其相关分子被分为 I 型干扰素，其他两类分别为 II 型干扰素 (IFN-γ) 和 III 型干扰素 (IFN-λ)[1]。干扰素 α (IFN-α) 在各种癌症中显示出显著的生物活性，特别是血液系统恶性肿瘤，如毛细胞白血病和慢性骨髓性白血病[2].
干扰素-α4 (IFNA4) 是 IFN-α 中占主导的亚型，其与 IFNA5、IFNA7 和 IFNA14 的应答占外周血单个核细胞 (PBMCs) 表达的亚型的 85%[3]。干扰素-α4 由干扰素 (IFN) 调节因子 (IRFs) 促进表达，尤其是 IRF-1 和 IRF-7[5][6]。它具有抑制病毒 RNA 复制的作用，能够增强人体自然杀伤细胞毒性来对抗病毒[4][7].

IFN-alpha 4 (IFNA4; IFN-α4), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively[1].
Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia[2].
IFN-alpha 4 is the subtypes dominates in IFN-alpha, whose the response with IFNA5, IFNA7, and IFNA14 accounting for up to 85% of the subtypes expressed by Peripheral blood mononuclear cells (PBMCs)[3].
IFN-alpha 4 is promoted by interferon (IFN) regulatory factors (IRFs), especially IRF-1 and IRF-7[5][6]. And it exhibits function by inhibiting virus RNA replication and enhances human natural killer cytotoxicity against virus[4][7].

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