1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-20 Receptor
  5. IL-20R beta

IL-20R beta  (白介素-20 受体 β)

白介素-20 受体 β (IL-12RB),属于 II 型细胞因子受体家族。IL-12RB 在组织中广泛表达,在皮肤和睾丸中表达最高。IL-12RB 与不同亚基蛋白形成功能性异二聚体参与激活 STAT3 通路[1]。IL-12RB 通过与 IL20RA 二聚成为 IL-19、IL-20 和 IL-24 的受体,而通过与 IL-22RA1 二聚成为 IL-20 和 IL-24 的受体[2]
IL-20RB/IL-20RA 和 IL-20RB/IL-22RA1 通过结合 IL-20 发挥作用,然后在角化细胞系中通过 STAT3 刺激信号转导通路。并且,IL-20RB/IL-20RA 在银屑病皮损角质形成细胞中表达上调[3]
IL-20RB/IL-20RA 和 IL-20RB/IL-22RA1 与 IL-24 结合,诱导 Stat-1 和 Stat-3 转录因子快速激活,似乎在细胞生存和增殖中起作用[4].

IL-20R beta (IL-12RB), also known as a beta subunit of IL-20 receptor (IL-20RB), belongs to the type II cytokine receptor family. IL-20R beta is widely expressed with highest levels in skin and testis and highly expressed in psoriatic skin[1]. IL-20R beta forms functional heterodimers with different subunit protein involves in STAT3 activation pathway. IL-20R beta serves as the receptor for IL-19, IL-20 and IL-24 by dimerizing with IL20RA, however serves as the receptor for IL-20 and IL-24 by dimerizing with IL-22RA1[2].
IL-20RB/IL-20RA and IL-20RB/IL-22RA1, act function by binding IL-20, and then stimulates a signal transduction pathway through STAT3 in a keratinocyte cell line[1]. However, the expression of both IL-20RB/IL-20RA is found to be upregulated in psoriatic skin lesions on keratinocytes[3].
IL-20RB/IL-20RA and IL-20RB/IL-22RA1 bind to IL-24, induce rapid activation of Stat-1 and Stat-3 transcription factors, which appear to play a role in cell survival and proliferation[4].

目录号 产品名 / 同用名 种属 表达系统
  • HY-P72561
    IL-20R beta Protein, Human (HEK293, Fc)

    重组人 IL-20R beta 蛋白 (HEK293, Fc)

    Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1

    Human HEK293
    IL-20R beta 蛋白 (IL20RB) 是 IL-20 受体的 β 亚基,与不同亚基蛋白形成功能性异二聚体,参与 STAT3 通路激活。IL-20RA/IL-20RB 二聚体是 IL-19、IL-20 和 IL-24 的受体,而 IL-22RA1/IL-20RB 二聚体是 IL-20 和 IL-24的受体。IL-20R alpha 蛋白由 311 个氨基酸 (M1-S311) 组成,具有跨膜结构域 (230-254 a.a.)。重组猕猴 IL-20R beta 蛋白 (HEK293, His),含有纤维连接蛋白 III 型结构域,由 HEK293 细胞表达,带有 C 末端 His 标签。
  • HY-P76429
    IL-20R beta Protein, Mouse (HEK293, His)

    重组小鼠 IL-20R beta 蛋白 (HEK293, His)

    Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1

    Mouse HEK293
    IL-20R beta Protein (IL20RB) is the beta subunit of IL-20 receptor, forms functional heterodimers with different subunit protein and involves in STAT3 activation pathway. The IL-20RA/IL-20RB dimer is a receptor for IL-19, IL-20 and IL-24. The IL-22RA1/IL-20RB dimer is a receptor for IL-20 and IL-24. IL-20R beta Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal hFc-tag.
  • HY-P77000
    IL-20R beta Protein, Rat (HEK293, His)

    重组大鼠 IL-20R beta 蛋白 (HEK293, His)

    Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1

    Rat HEK293
    IL-20R beta 蛋白 (IL20RB) 是 IL-20 受体的 β 亚基,与不同亚基蛋白形成功能性异二聚体,参与 STAT3 通路激活。IL-20RA/IL-20RB 二聚体是 IL-19、IL-20 和 IL-24 的受体,而 IL-22RA1/IL-20RB 二聚体是 IL-20 和 IL-24的受体。IL-20R alpha 蛋白由 308 个氨基酸 (M1-T308) 组成,具有跨膜结构域 (226-249 a.a.)。重组大鼠 IL-20R beta 蛋白 (HEK293, Fc),由 HEK293 细胞表达,带有 C 末端 hFc 标签。
  • HY-P77422
    IL-20R beta Protein, Cynomolgus (HEK293, His)

    重组猕猴 IL-20R beta 蛋白 (HEK293, His)

    Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1

    Cynomolgus HEK293
    IL-20R beta 蛋白 (IL20RB) 是 IL-20 受体的 β 亚基,与不同亚基蛋白形成功能性异二聚体,参与 STAT3 通路激活。IL-20RA/IL-20RB 二聚体是 IL-19、IL-20 和 IL-24 的受体,而 IL-22RA1/IL-20RB 二聚体是 IL-20 和 IL-24的受体。IL-20R beta 蛋白由 311 个氨基酸 (M1-S311) 组成,具有跨膜结构域 (230-254 a.a.)。重组猕猴 IL-20R beta 蛋白 (HEK293, His),含有纤维连接蛋白 III 型结构域,由 HEK293 细胞表达,带有 C 末端 His 标签。
  • HY-P76428
    IL-20R beta Protein, Human (sf9, His)

    重组人 IL-20R beta 蛋白 (sf9, His)

    Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1

    Human Sf9 insect cells
    IL-20R beta 蛋白 (IL20RB) 是 IL-20 受体的 β 亚基,与不同亚基蛋白形成功能性异二聚体,参与 STAT3 通路激活。IL-20RA/IL-20RB 二聚体是 IL-19、IL-20 和 IL-24 的受体,而 IL-22RA1/IL-20RB 二聚体是 IL-20 和 IL-24的受体。IL-20R alpha 蛋白由 311 个氨基酸 (M1-S311) 组成,具有跨膜结构域 (234-254 a.a.)。重组人 IL-20R beta 蛋白 (sf9, His),由 Sf9 昆虫细胞表达,带有 C 末端 His 标签。
  • HY-P77421
    IL-20R beta Protein, Cynomolgus (HEK293, Fc)

    重组猕猴 IL-20R beta 蛋白 (HEK293, Fc)

    Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1

    Cynomolgus HEK293
    IL-20R beta 蛋白 (IL20RB) 是 IL-20 受体的 β 亚基,与不同亚基蛋白形成功能性异二聚体,参与 STAT3 通路激活。IL-20RA/IL-20RB 二聚体是 IL-19、IL-20 和 IL-24 的受体,而 IL-22RA1/IL-20RB 二聚体是 IL-20 和 IL-24的受体。IL-20R alpha 蛋白由 308 个氨基酸 (M1-T308) 组成,具有跨膜结构域 (226-249 a.a.)。重组大鼠 IL-20R beta 蛋白 (HEK293, His),由 HEK293 细胞表达,带有 C 末端 His 标签。
  • HY-P76999
    IL-20R beta Protein, Rat (HEK293, Fc)

    重组大鼠 IL-20R beta 蛋白 (HEK293, Fc)

    Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1

    Rat HEK293
    IL-20R beta 蛋白 (IL20RB) 是 IL-20 受体的 β 亚基,与不同亚基蛋白形成功能性异二聚体,参与 STAT3 通路激活。IL-20RA/IL-20RB 二聚体是 IL-19、IL-20 和 IL-24 的受体,而 IL-22RA1/IL-20RB 二聚体是 IL-20 和 IL-24的受体。重组小鼠 IL-20R beta 蛋白 (HEK293, His),由 HEK293 细胞表达,全长 225 个氨基酸 (M1-S225),带有 C 末端 His 标签。
目录号 产品名 作用方式 纯度