2. MAPK/ERK Pathway
  3. p38 MAPK
  4. PS-166276

PS-166276 是一种强效且细胞毒性较低的 p38 抑制剂。PS166276 对 p38 激酶的 IC50 值为 28 nM，在 THP-1 TNFα 测定中的 IC50值为 170 nM。

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PS-166276 Chemical Structure

PS-166276 Chemical Structure

CAS No. : 348089-57-6

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PS-166276 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PS-166276 is a highly potent and less cytotoxic inhibitor of p38. PS166276 has an IC50 of 28 nM at p38 kinase and 170 nM in the THP-1 TNFα assay[1].

体内研究
(In Vivo)

PS166276 (30 mg/kg, s.c. mice) 在老鼠中抑制 LPS 诱导的 TNFα 产生。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

398.51

Formula

C20H30N8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PS-166276 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PS-166276348089-57-6PS166276PS 166276p38 MAPKp38THP-1TNFαLPSInhibitorinhibitorinhibit

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产品名称：
PS-166276
目录号：
HY-167877
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