2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. PVP-037.2

PVP-037.2 是一种 TLR7/8 激动剂。PVP-037.2 可作为辅助佐剂增强疫苗诱导 TH1 型免疫反应，增强抗原特异性抗体 IgG1和 IgG2c 的产生。

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PVP-037.2 Chemical Structure

PVP-037.2 Chemical Structure

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PVP-037.2 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PVP-037.2 is a TLR7/8 agonist. PVP-037.2 can serve as an adjuvant to enhance vaccine-induced TH1 type immune responses, increasing the production of antigen-specific antibodies IgG1 and IgG2c[1].

IC50 & Target

TLR7

 

TLR8

 

体外研究
(In Vitro)

PVP-037.2 (0.1-100 μM，24 小时) 以浓度依赖的方式诱导了人类老年外周血单核细胞 (PBMCs) 中的 TNF 和 IL-1β 的产生[1]。
PVP-037.2 (100 μM，20-24 小时) 具有依赖于 TLR7/8 的免疫调节特性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PVP-037.2 相关抗体:
体内研究
(In Vivo)

PVP-037.2 (3 mg/kg，静脉注射，给药后 0-8 小时测定) 在 C57BL/6J 成年小鼠 (体重为 20 至 30 g) 中具有高血浆清除率且几乎无溶血活性[1]。
PVP-037.2 (每只小鼠 100 nmol，静脉注射，单次免疫接种) 在接种三价重组 rHA 流感疫苗 Flublok及 SARS-CoV-2 刺突蛋白的 C57BL/6J 小鼠中具有强大的佐剂作用[1]。
与单独使用 PVP-037.2 相比，PVP-037.2 O/W 乳液制剂 (每只小鼠 10 nmol，静脉注射，第 42 天测定 IgG 滴度) 可使野生型 C57BL/6J 小鼠的先天免疫激活能力增强[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WT C57BL/6J mice
Dosage: 10 nmol per mouse
Administration: Intravenous injection (i.v.), single injection
Result: Significantly enhanced total IgG and IgG2c class-switched antibody responses (IgG titers measured on day 42).
Animal Model: C57BL/6J mice (6 to 8 weeks old, stimulated with the trivalent recombinant rHA influenza vaccine Flublok and the SARS-CoV-2 spike protein)
Dosage: 100 nmol per mouse
Administration: Intravenous injection (i.v.), single injection
Result: Resulted that the production of antigen-specific IgG1 and IgG2c was significantly enhanced in C57BL/6J mice stimulated with the trivalent recombinant rHA influenza vaccine Flublok (IgG titers measured on day 28) and the SARS-CoV-2 spike protein (IgG titers measured on day 42).
分子量

439.43

Formula

C23H20F3N5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PVP-037.2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PVP-037.2Toll-like Receptor (TLR)Peripheral blood mononuclear cells (PBMCs)C57BL/6J mice model (stimulated with the trivalent recombinant rHA influenza vaccine Flublok and the SARS-CoV-2 spike protein)AdjuvanticityInflammation/ImmunologyInhibitorinhibitorinhibit

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产品名称：
PVP-037.2
目录号：
HY-159102
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