2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. PYRIB-SO 2

PYRIB-SO 2 是一种有效的抗有丝分裂 (mitotic) 剂。PYRIB-SO 2 显示抗增殖活性并诱导细胞周期停滞在 G2/M 期。PYRIB-SO 2 减少并破坏微管结构。PYRIB-SO 2 与 α, β-微管蛋白的秋水仙碱结合位点 (C-BS) 结合。

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PYRIB-SO 2 Chemical Structure

PYRIB-SO 2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

PYRIB-SO 2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PYRIB-SO 2 is a potent antimitotic agent. PYRIB-SO 2 shows antiproliferative activity and induces cell cycle arrest at G2/M phase. PYRIB-SO 2 reduces and disruptes microtubule structures. PYRIB-SO 2 binds to the colchicine-binding site (C-BS) of α, β-tubulin[1].

体外研究
(In Vitro)

PYRIB-SO 2 (150 nM; 24 h) 诱导细胞周期停滞在 G2/M 期[1]。
PYRIB-SO 2 (138 Nm; 24 h) 可减少并破坏 MCF7 细胞中的微管结构[1]。
PYRIB-SO 2 (5, 50 µM) 减少 EBI:β-微管蛋白加合物的形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PYRIB-SO 2 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF7, MDA-MB-468, MDA-MB-231 cells
Concentration: 0-500 nM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50s of 50, 9, 220 nM for MCF7, MDA-MB-468 and MDA-MB-231 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF7 cells
Concentration: 150 nM
Incubation Time: 24 h
Result: Iduced cell cycle arrest at G2/M phase with the percentage of 77%.
分子量

353.78

Formula

C14H12ClN3O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PYRIB-SO 2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PYRIB-SO 2Microtubule/TubulinMCF7 cellsantiproliferativeG2/M phaseEBI:β-tubulinInhibitorinhibitorinhibit

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目录号：
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