(R)-Plevitrexed  (Synonyms: (R)-普来曲塞; (R)-ZD 9331; (R)-BGC9331)

(R)-Plevitrexed ((R)-ZD 9331; (R)-BGC9331) is a less active enantiomer of Plevitrexed^[1]. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor^[2]. (R)-Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

532.53

C₂₆H₂₅FN₈O₄

153537-74-7

(R)-普来曲塞

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Marsham PR, et al. Design and synthesis of potent non-polyglutamatable quinazoline antifolatethymidylate synthase inhibitors. J Med Chem. 1999 Sep 23;42(19):3809-20.  [Content Brief]

  [2]. Tochowicz A, et al. Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11;56(13):5446-55.  [Content Brief]