2. Epigenetics
  3. Epigenetic Reader Domain
  4. (R)-SR-C-107

(R)-SR-C-107 是基于 ENL (含 YEAST 结构域蛋白) 抑制剂，设计而成的具有口服有效性的、抗急性髓系白血病 (AML) 的抑制剂。(R)-SR-C-107 靶向 ENL 的 IC50 和 KD 分别为 40 nM 和 144 nM。(R)-SR-C-107 在异种移植 AML 的小鼠模型中发挥了体内效力，200 mg/kg (PO; QD) 剂量下的肿瘤消退率为 45%。

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(R)-SR-C-107 Chemical Structure

(R)-SR-C-107 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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(R)-SR-C-107 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R)-SR-C-107 is an orally available inhibitor of ENL (YEAST domain-containing protein) designed to target acute myeloid leukemia (AML). (R)-SR-C-107 targets ENL with IC50 and KD of 40 nM and 144 nM, respectively. (R)-SR-C-107 demonstrates in vivo efficacy in a xenograft mouse model of AML, with a tumor regression rate of 45% at a dose of 200 mg/kg (PO; QD)[1].

分子量

389.45

Formula

C21H23N7O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(R)-SR-C-107 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-SR-C-107Epigenetic Reader DomainInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-169937
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