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  4. R892

R892是一种选择性且高效的 bradyKinin B1 受体拮抗剂，具有显著的拮抗活性。R892在人体和兔子B1受体中的pA2值分别为8.8和8.6，显示其在这些受体上具有强大的抗活动性。R892对B1和B2受体的ID50值分别为2.8 nM和> 600 nM，表现出其选择性，并且没有内源性激动剂活性。R892对氨基肽酶和激肽酶 II（ACE）降解具有抵抗力，展现出代谢稳定性。

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R892 Chemical Structure

R892 Chemical Structure

CAS No. : 229030-05-1

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R892 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

R892 is a selective and efficient bradyKinin B1 receptor antagonist with significant antagonistic activity. The pA2 values of R892 in human and rabbit B1 receptors are 8.8 and 8.6 respectively, indicating its strong anti-activity at these receptors. R892 exhibits selectivity with ID50 values of 2.8 nM and >600 nM for B1 and B2 receptors, respectively, and has no endogenous agonist activity. R892 is resistant to aminopeptidase and kininase II (ACE) degradation and exhibits metabolic stability[1].

分子量

1154.36

Formula

C58H83N13O12
CAS 号
Sequence

Ac-Lys-Arg-Pro-Pro-Gly-{Phe<Me>}-Ser-{d-Nal}-Ile
Sequence Shortening

Ac-KRPPG-{Phe<Me>}-SA-{d-Nal}-I
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

R892 相关分类

  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R892229030-05-1R 892R-892OthersInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-103294
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