GRF (1-29) amide (rat) (Synonyms: rGHRH(1-29)NH2)

目录号: HY-P1155 纯度: 99.94%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

GRF (1-29) amide (rat) 是能刺激生长激素 (GH) 分泌的合成肽。

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Custom Peptide Synthesis

GRF (1-29) amide (rat) Chemical Structure

CAS No. : 91826-20-9

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规格	价格	是否有货
1 mg	￥900	In-stock
5 mg	￥2250	In-stock
10 mg	￥3350	In-stock
50 mg		询价
100 mg		询价

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Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献

•Environ Sci Technol. 2021 Jun 1. [Abstract]

GRF (1-29) amide (rat) 相关产品

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

GRF (1-29) amide (rat) is a synthetic peptide which can stimulate the growth hormone (GH) secretion.

体内研究
(In Vivo)

Time course studies of GRF (1-29) amide (rat) disappearance show apparent half-lives of 18±4 min and 13±3 min in serum and liver homogenate, respectively. This is accompanied by the appearance of degradation products that are all less hydrophobic than the native peptide. In the serum, two major metabolites are detected and isolated by preparative HPLC^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3473.08

Formula

C₁₅₅H₂₅₁N₄₉O₄₀S

CAS 号

91826-20-9

性状

固体

颜色

White to off-white

Sequence

His-Ala-Asp-Ala-Ile-Phe-Thr-Ser-Ser-Tyr-Arg-Arg-Ile-Leu-Gly-Gln-Leu-Tyr-Ala-Arg-Lys-Leu-Leu-His-Glu-Ile-Met-Asn-Arg-NH2

Sequence Shortening

HADAIFTSSYRRILGQLYARKLLHEIMNR-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

细胞实验：

H₂O 中的溶解度 : 16.67 mg/mL (4.80 mM; 超声助溶)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2879 mL	1.4396 mL	2.8793 mL
5 mM	---	---	---
10 mM	---	---	---

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

纯度: 99.94%

选择批次：

Data Sheet (596 KB) SDS (393 KB)

COA (280 KB) LCMS (91 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Boulanger L, et al. Catabolism of rat growth hormone-releasing factor(1-29) amide in rat serum and liver. Peptides. 1992 Jul-Aug;13(4):681-9. [Content Brief]

Cell Assay ^[1]	To isolate GRF metabolites in the liver, rGRF(1-29)NH₂ (10 mg) is first preincubated in 232 mL of Krebs' buffer (5 min, 37°C) to help GRF solubilization and then incubated with a liver homogenate in a shaking bath at 37°C. The homogenate is prepared as in the degradation assays with 580 mg of liver (10 mg/mL). The reaction is stopped after 30 min by adding 174 mL of cold 50 mM phosphate solution (pH 0.8) and centrifugation (48,000×g, 20 min, 4°C). The supernatant is filtered twice and its pH is adjusted (3.0) with 6 N NaOH before chromatography. The GRF metabolites and residual rGRF(1-29)NH₂ are isolated^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Boulanger L, et al. Catabolism of rat growth hormone-releasing factor(1-29) amide in rat serum and liver. Peptides. 1992 Jul-Aug;13(4):681-9. [Content Brief]

Cell Assay
^[1]

To isolate GRF metabolites in the liver, rGRF(1-29)NH₂ (10 mg) is first preincubated in 232 mL of Krebs' buffer (5 min, 37°C) to help GRF solubilization and then incubated with a liver homogenate in a shaking bath at 37°C. The homogenate is prepared as in the degradation assays with 580 mg of liver (10 mg/mL). The reaction is stopped after 30 min by adding 174 mL of cold 50 mM phosphate solution (pH 0.8) and centrifugation (48,000×g, 20 min, 4°C). The supernatant is filtered twice and its pH is adjusted (3.0) with 6 N NaOH before chromatography. The GRF metabolites and residual rGRF(1-29)NH₂ are isolated^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Boulanger L, et al. Catabolism of rat growth hormone-releasing factor(1-29) amide in rat serum and liver. Peptides. 1992 Jul-Aug;13(4):681-9. [Content Brief]

GRF (1-29) amide (rat) 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O

1 mM

0.2879 mL

1.4396 mL

2.8793 mL

7.1982 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GRF (1-29) amide (rat)91826-20-9rGHRH(1-29)NH2OthersInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GRF (1-29) amide (rat) (Synonyms: rGHRH(1-29)NH2)

Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献