2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. (Rac)-Deox B 7,4

(Rac)-Deox B 7,4  (Synonyms: (Rac)-Deoxysappanone B 7,4' dimethyl ether)

目录号: HY-119361
产品使用指南

摩尔计算器

(Rac)-Deox B 7,4 一种同型异黄酮化合物，通过在秋水仙碱位点附近的结合抑制微管聚合，促进可逆的 G2 阻滞。(Rac)-Deox B 7,4具有抗白血病活性。

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(Rac)-Deox B 7,4 Chemical Structure

(Rac)-Deox B 7,4 Chemical Structure

CAS No. : 674786-37-9

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(Rac)-Deox B 7,4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Rac)-Deox B 7,4, a homoisoflavanoid compound, inhibits microtubule polymerization via binding near the colchicine site and promote reversible G2 arrest. (Rac)-Deox B 7,4 possesses nanomolar anti-leukemic activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BT-549 IC50
30.6 μM
Compound: 3o
Cytotoxicity against human BT549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human BT549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 29074256]
HeLa IC50
50.12 μM
Compound: 3o
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 29074256]
Vero IC50
> 200 μM
Compound: 3o
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 29074256]
体外研究
(In Vitro)

(Rac)-Deox B 7,4 可降低多种AML细胞系的生长和活力 (IC50 值范围 324-556 nM)。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(Rac)-Deox B 7,4 相关抗体:
分子量

314.33

Formula

C18H18O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Rac)-Deox B 7,4 相关分类

  • 摩尔计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Deox B 7,4674786-37-9(Rac)-Deoxysappanone B 7,4' dimethyl etherMicrotubule/TubulinTEXHL-60OCI-AML-2K562THP-1,Inhibitorinhibitorinhibit

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