2. Apoptosis
  3. Apoptosis
  4. (Rac)-Idroxioleic acid sodium

(Rac)-Idroxioleic acid sodium  (Synonyms: 2-Hydroxyoleic acid sodium; 2-OHOA sodium; LAM561 sodium)

目录号: HY-129467A
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(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium 是一种合成油酸 (OA) 衍生物，能与质膜结合改变脂质组织。(Rac)-Idroxioleic acid sodium 具有抗肿瘤作用。

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(Rac)-Idroxioleic acid sodium Chemical Structure

(Rac)-Idroxioleic acid sodium Chemical Structure

CAS No. : 1229114-68-4

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(Rac)-Idroxioleic acid sodium 的其他形式现货产品:

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(Rac)-Idroxioleic acid sodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid sodium has anti-tumor effect[1].

体外研究
(In Vitro)

(Rac)-Idroxioleic acid sodium (25-75 μM, 72 小时) 以时间和浓度依赖性的方式损害 Jurkat 细胞的生长，IC50 值约 40 μM[1].
(Rac)-Idroxioleic acid sodium (25-50 μM, 72 小时) 也能显著且浓度依赖性地增加 PARP 的蛋白酶切割，这是一个细胞凋亡的分子标记[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(Rac)-Idroxioleic acid sodium 相关抗体:

Cell Viability Assay[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM, 75 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Impaired Jurkat cell growth in a time- and concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM
Incubation Time: 72 hours
Result: Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.
体内研究
(In Vivo)

(Rac)-Idroxioleic acid sodium 显著且明显地抑制了感染 Jurkat 细胞的小鼠肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model)[1]
Dosage: 600 mg/kg
Administration: Oral administration; daily; for 21 days
Result: Markedly and significantly inhibited tumour growth.
分子量

320.44

Formula

C18H33NaO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Rac)-Idroxioleic acid sodium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Idroxioleic acid1229114-68-42-Hydroxyoleic acid2-OHOALAM561LAM 561LAM-561ApoptosisoleicacidplasmamembraneInhibitorinhibitorinhibit

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