ACE2 蛋白, Cynomolgus (Biotinylated, HEK293, His-Avi)

ACE2 Protein, an indispensable counter-regulatory carboxypeptidase within the renin-angiotensin hormone system, plays a pivotal role in maintaining cardiovascular homeostasis by intricately regulating blood volume and systemic vascular resistance. ACE2 exhibits broad enzymatic activity, cleaving various vasoactive peptides such as neurotensin, kinetensin, and des-Arg bradykinin. Moreover, ACE2 is proficient in cleaving other biological peptides, including apelins, casomorphins, and dynorphin A. ACE2 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived ACE2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of ACE2 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is 722 a.a., with molecular weight of 87-110 kDa.

血管紧张素转换酶 2 (ACE2) 是肾素-血管紧张素激素系统中不可或缺的反调节羧肽酶，通过复杂地调节血容量和全身血管阻力，在维持心血管稳态中发挥着关键作用。通过其酶活性，ACE2 将血管紧张素 I 转化为血管紧张素 1-9，将血管紧张素 II 转化为血管紧张素 1-7，在心肌细胞中发挥抗肥厚作用，并作为具有抗增殖特性的血管舒张剂。除了在肾素-血管紧张素系统中发挥核心作用外，ACE2 还表现出广泛的酶活性，可裂解各种血管活性肽，例如神经降压素、运动紧张素和去精氨酸缓激肽。此外，ACE2 还擅长切割其他生物肽，包括 apelins、casomorphins 和强啡肽 A。值得注意的是，ACE2 的 C 末端与 collectrin 同源，协调中性氨基酸转运蛋白 SL6A19 向肠上皮细胞膜的运输，从而调节其表面表达和催化活性。重要的是，ACE2 还充当人类冠状病毒 SARS-CoV、SARS-CoV-2 和 HCoV-NL63 的受体，这表明它与微生物感染途径有关^[1][2][3][4]。

Cynomolgus

HEK293

C-Avi;C-His

A0A2K5X283 (Q18-V739)

102130864  [NCBI]

87-110 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.