ACE2 蛋白, Rhesus Macaque (HEK293, Fc)

ACE2 Protein, an indispensable counter-regulatory carboxypeptidase within the renin-angiotensin hormone system, plays a pivotal role in maintaining cardiovascular homeostasis by intricately regulating blood volume and systemic vascular resistance. ACE2 exhibits broad enzymatic activity, cleaving various vasoactive peptides such as neurotensin, kinetensin, and des-Arg bradykinin. Moreover, ACE2 is proficient in cleaving other biological peptides, including apelins, casomorphins, and dynorphin A. ACE2 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived ACE2 protein, expressed by HEK293 , with C-hFc labeled tag.

血管紧张素转换酶 (ACE2) 是肾素-血管紧张素激素系统中不可或缺的反调节羧肽酶，通过复杂地调节血容量和全身血管阻力，在维持心血管稳态中发挥着关键作用。通过其酶活性，ACE2 将血管紧张素 I 转化为血管紧张素 1-9，将血管紧张素 II 转化为血管紧张素 1-7，在心肌细胞中发挥抗肥厚作用，并作为具有抗增殖特性的血管舒张剂。除了在肾素-血管紧张素系统中发挥核心作用外，ACE2 还表现出广泛的酶活性，可裂解各种血管活性肽，例如神经降压素、运动紧张素和去精氨酸缓激肽。此外，ACE2 还擅长切割其他生物肽，包括 apelins、casomorphins 和强啡肽 A。值得注意的是，ACE2 的 C 末端与collectrin 同源，协调中性氨基酸转运蛋白 SL6A19 向肠上皮细胞膜的运输，从而调节其表面表达和催化活性。重要的是，ACE2 还充当人类冠状病毒 SARS-CoV、SARS-CoV-2 和 HCoV-NL63 的受体，这表明它与微生物感染途径有关^[1][2]。

Rhesus Macaque

HEK293

C-hFc

ACI04564.1 (Q18-V739)

712790  [NCBI]

MSGSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGEKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPNNPQECLLLDPGLNEIMEKSLDYNERLWAWEGWRSEVGKQLRPLYEEYVVLKNEMARANHYKDYGDYWRGDYEVNGVDGYDYNRDQLIEDVERTFEEIKPLYEHLHAYVRAKLMNAYPSYISPTGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVNQAWNAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKVVCHPTAWDLGKGDFRIIMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKDEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLLNMLKLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRTYFLEIKHQTILFGEEDVRVADLKPRISFNFYVTAPKNVSDIIPRTEVEEAIRISRSRINDAFRLNDNSLEFLGIQTTLAPPYQSPV

Approximately 110.7 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.