AGR3 蛋白, Mouse (HEK293, His)

AGR3 Protein, Mouse (HEK293, His) is a mouse recombinant Agr3 with a His tag at the C-terminus.Recombinant is produced by Mammalian expression system and the target gene encoding Ile21-Leu165 is expressed.

前梯度蛋白 3 (AGR3) 是促癌 AGR2 的同源物。AGR3 和 AGR2 具有 71% 的序列同一性，并且在染色体位置 7p2 处彼此相邻。从功能上讲，它们属于蛋白质二硫键异构酶（PDI）家族，作为内质网（ER）驻留分子折叠酶参与维持细胞稳态。AGR3 是一种内质网驻留蛋白，是调节气道上皮纤毛跳动频率和粘膜纤毛清除所必需的。AGR3 显示与dystroglycan-1 (DAG-1) 和转移相关C4.4A 蛋白相互作用，表明其作为转移驱动因素的潜力。AGR3是抗肿瘤治疗的一个潜在有前景的靶标。据报道，某些癌症类型中 AGR3 表达水平升高，包括乳腺癌、肝癌、前列腺癌和卵巢癌^[1]。

Mouse

HEK293

C-6*His

Q8R3W7 (I21-L165)

403205  [NCBI]

IAIKKEKRPPQTLSRGWGDDITWVQTYEEGLFHARKSNKPLMVIHHLEDCQYCQALKKEFAKNEEIQEMAQNDFIMLNLMHETTDKNLSPDGQYVPRIMFVDPSLTVRADITGRYSNRLYTYEPQDLPMLVDNMKKALRLIQSELHHHHHH

Approximately 16-18 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filter solution of 20 mM Tris, 100 mM NaCl, 10% Glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. Obacz J, et al. Extracellular AGR3 regulates breast cancer cells migration via Src signaling. Oncol Lett. 2019 Nov;18(5):4449-4456.  [Content Brief]