AIF1 蛋白, Human (N-His)

The AIF1 protein is an actin-binding promoter that enhances membrane ruffling, activates RAC, and amplifies the actin-bundling activity of LCP1. This calcium-binding protein has a critical impact on RAC signaling, phagocytosis, and may contribute to macrophage function. AIF1 Protein, Human (N-His) is the recombinant human-derived AIF1 protein, expressed by E. coli , with N-His labeled tag. The total length of AIF1 Protein, Human (N-His) is 147 a.a., with molecular weight of ~19 kDa.

AIF1 是一种肌动蛋白结合蛋白，可作为膜扰乱和 RAC 激活的促进剂，并增强 LCP1 的肌动蛋白捆绑活性。这种钙结合蛋白在 RAC 信号传导、吞噬作用中发挥着至关重要的作用，并可能有助于巨噬细胞的激活和功能。AIF1 参与促进血管平滑肌细胞和 T 淋巴细胞的增殖，以及增强淋巴细胞的迁移。此外，它还参与血管炎症。AIF1 可以作为同二聚体（潜在）或单体存在，并与 LCP1 相互作用，表明它参与了控制细胞过程的复杂分子相互作用。

Human

E. coli

N-His

P55008 (M1-P147)

199  [NCBI]

MSQTRDLQGGKAFGLLKAQQEERLDEINKQFLDDPKYSSDEDLPSKLEGFKEKYMEFDLNGNGDIDIMSLKRMLEKLGVPKTHLELKKLIGEVSSGSGETFSYPDFLRMMLGKRSAILKMILMYEEKAREKEKPTGPPAKKAISELP

Approximately 19 KDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 300 mM NaCl, 5% trehalose, 5% mannitol and 0.01% Tween80, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.