AMHR2/MISRII 蛋白, Cynomolgus/Rhesus Macaque (HEK293, Fc)

AMHR2/MISRII Protein is expressed in a large number of female reproductive organs. AMHR2 Protein, upon ligand binding, assembles a receptor complex with two type II and two type I transmembrane serine/threonine kinases. Type II receptors initiate the signaling cascade by phosphorylating and activating type I receptors, which undergo autophosphorylation. Activated type I receptors then engage and activate SMAD transcriptional regulators, modulating downstream gene expression. Furthermore, AMHR2 serves as the receptor for anti-Muellerian hormone. AMHR2/MISRII Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant cynomolgus, Rhesus Macaque-derived AMHR2/MISRII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of AMHR2/MISRII Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 127 a.a., with molecular weight of 55-60 kDa.

抗苗勒氏激素 2 型受体 (AMHR2) 在大量女性生殖器官中表达。其表达主要受骨形态发生蛋白、促性腺激素和雌激素的调节。AMHR2 在配体结合后，与两种 II 型和两种 I 型跨膜丝氨酸/苏氨酸激酶组装受体复合物。II 型受体通过磷酸化和激活 I 型受体来启动信号级联，而 I 型受体又进行自身磷酸化。随后，这些激活的 I 型受体与 SMAD 转录调节因子结合并激活，最终调节下游基因表达。值得注意的是，AMHR2 作为抗苗勒氏激素的受体，在介导该激素触发的细胞反应中发挥着关键作用。AMHR2 基因突变与 II 型持续苗勒氏管综合征相关^[1]。

Rhesus Macaque; Cynomolgus

HEK293

C-hFc

XP_001105261 (P18-S144)

702822  [NCBI]

55-60 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.