1. 重组蛋白
  2. Enzymes & Regulators
  3. Hydrolases (EC 3)
  4. AMSHLP 蛋白, Human (His)

AMSHLP 蛋白, Human (His)

目录号: HY-P701459
产品使用指南

AMSHLP 是一种锌金属蛋白酶,可选择性裂解“Lys-63”连接的多聚泛素链,并充当 TORC1 信号通路的正调节因子。它特异性去泛素化 SESN2,破坏其与 GATOR2 复合物的相互作用,并抑制 SESN2 介导的 TORC1 调节。AMSHLP 蛋白, Human (His) 是重组的 AMSHLP 蛋白,由 E. coli 表达,带有 N-6*His 标签。AMSHLP 蛋白, Human (His) 全长 435 个氨基酸。

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描述

AMSHLP is a zinc metalloprotease that selectively cleaves "Lys-63" linked polyubiquitin chains and acts as a positive regulator of the TORC1 signaling pathway. It specifically deubiquitinates SESN2, disrupts its interaction with the GATOR2 complex and inhibits SESN2-mediated regulation of TORC1. AMSHLP Protein, Human (His) is the recombinant human-derived AMSHLP protein, expressed by E. coli , with N-6*His labeled tag. The total length of AMSHLP Protein, Human (His) is 435 a.a., .

研究背景

AMSHLP 是一种锌金属蛋白酶,具有选择性裂解“Lys-63”连接的多聚泛蛋白链,而不影响“Lys-48”连接的多聚泛蛋白链。值得注意的是,AMSHLP 通过其在 SESN2 的“Lys-63”相关去泛素化中的作用,充当 TORC1 信号通路的正调节因子。这种去泛素化活性阻碍了 SESN2 和 GATOR2 复合物之间的相互作用,从而有助于抑制 SESN2 介导的 TORC1 调节。这些功能强调了 AMSHLP 通过精确调节“Lys-63”连接的多聚泛素链,具体参与微调细胞信号传导途径,特别是与 TORC1 相关的信号传导途径。

种属

Human

表达系统

E. coli

标签

N-6*His

蛋白编号

Q96FJ0 (D2-R436)

基因 ID

57559

蛋白结构
N-term
6*His
AMSHLP (D2-R436)
Accession # Q96FJ0
C-term
同用名
STAMBP; STAM-binding protein; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase
纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

AMSHLP Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
AMSHLP Protein, Human (His)
目录号:
HY-P701459
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