Angiogenin-4 蛋白, Mouse (P.pastoris, His-SUMOstar)

The angiopoietin-4 protein has specific bactericidal activity against Enterococcus faecalis and Listeria monocytogenes, distinct from its lack of efficacy against Lactobacillus innocua and Escherichia coli. Furthermore, Angiogenin-4 exerts pro-angiogenic effects in vitro, suggesting its involvement in supporting the formation of new blood vessels. Angiogenin-4 Protein, Mouse (P.pastoris) is the recombinant mouse-derived Angiogenin-4 protein, expressed by P. pastoris , with N-6*His, N-SUMO labeled tag. The total length of Angiogenin-4 Protein, Mouse (P.pastoris) is 120 a.a., with molecular weight of ~33 kDa.

血管生成素-4 (ANG4)，对粪肠球菌和单核细胞增生李斯特菌表现出显着的杀菌活性，其抗菌作用与众不同。然而，它没有表现出对无害乳杆菌和大肠杆菌的杀菌活性。除了抗菌作用外，ANG4 还在体外发挥促进血管生成的作用，表明它参与新血管的形成。尽管体外核糖核酸酶活性较低，但 ANG4 因其刺激黑色素瘤细胞增殖的能力而脱颖而出，而体外对内皮细胞或成纤维细胞则没有这种作用。ANG4 的这些多方面功能突出了其在宿主防御、血管生成和细胞增殖中的不同作用，这表明针对感染和癌症的治疗策略具有潜在的意义。进一步的研究对于揭示这些活动背后的具体分子机制至关重要。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Mouse

P. pastoris

N-6*His;N-SUMOstar

Q3TMQ6 (Q25-P144)

219033  [NCBI]

QNERYEKFLRQHYDAKPNGRDDRYCESMMKERKLTSPCKDVNTFIHGTKKNIRAICGKKGSPYGENFRISNSPFQITTCTHSGASPRPPCGYRAFKDFRYIVIACEDGWPVHFDESFISP

Approximately 33 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in 20 mM Tris-HC1, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.