Angiopoietin-2 蛋白, Cynomolgus/Rhesus Macaque (HEK293, Fc)

Angiopoietin-2 (Ang2) is a growth factor that belongs to the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway, which is one of the main pathways involved in angiogenesis. Ang2 is a 496 amino acid long protein with a secretory signal peptide, an NH2-terminal coiled-coil domain, and a COOH-terminal fibrinogen-like domain. Ang2 mainly inhibits Ang1-induced Tie2 phosphorylation. Ang2 is critical for endothelial cell physiology and plays a central role in vascular-related diseases by regulating endothelial permeability and angiogenic functions. Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 222 a.a., with molecular weight of ~53.8 KDa.

Ang2 是一种长 496 个氨基酸的蛋白质，与 Ang1 具有约 60% 的氨基酸同源性，并且缺乏成熟 Ang1 中发现的九个半胱氨酸之一。它具有分泌信号肽、NH2 末端卷曲螺旋结构域和 COOH 末端纤维蛋白原样结构域。与 Ang1 不同，Ang2 以自分泌方式发挥作用，其表达受到高度调控。与Ang1类似，Ang2以相同的结合亲和力与Tie2受体结合，诱导其拮抗作用，但不与Tie1结合。Ang2 表达由凝血酶等炎症介质和缺氧和癌症等条件触发^[1]。
ANGPT2 被描述为一种背景依赖性拮抗剂，干扰血管生成素-1 诱导的 Tie2 磷酸化，从而破坏血管稳定性并促进血管生成，可能会导致对抗血管生成治疗产生耐药性。ANGPT2被发现在多种肿瘤细胞中高表达，在肿瘤血管生成和炎症中发挥重要作用^[2]。

Rhesus Macaque

HEK293

N-hFc

XP_005562586 (K274-F495)

101925495  [NCBI]

Approximately 53.8 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.