ANGPTL7/Angiopoietin-related 7 蛋白, Canine (HEK293, His)

ANGPTL7/ Angiopoietin-related proteins are negative regulators of corneal angiogenesis and play an important role in maintaining the patency and transparency of corneal blood vessels. ANGPTL7 is regulated by SP1 transcription and regulates ANGPTL7 levels through the RhoA/ROCK signaling pathway mediating CLAN formation. ANGPTL7/Angiopoietin-related 7 Protein, Canine (HEK293, His) is the recombinant canine-derived ANGPTL7/Angiopoietin-related 7 protein, expressed by HEK293 , with C-His labeled tag.

ANGPTL7/血管生成素相关蛋白在细胞外基质的形成和组织中起着至关重要的作用。研究表明，特别是在眼睛中，它作为地塞米松诱导的基质沉积在小梁网中的介质，小梁网是眼房水流出和维持眼压所必需的组织。此外，ANGPTL7 是角膜血管生成的负调节因子，在保持角膜血管通畅和透明度方面发挥重要作用。ANGPTL7 受 SP1 转录调控，通过 RhoA/ROCK 信号通路调节 ANGPTL7 水平介导CLAN 形成。

Measured by its binding ability in a functional ELISA. When Recombinant Human LILRB2 Protein is immobilized at 5 µg/mL (100µL/well) can bind Biotinylated Canine ANGPTL7 Protein. The ED₅₀ for this effect is 0.848 μg/mL.

Canine

HEK293

C-6*His

XP_852356.1/A0A8C0QI96 (Q27-P344)

608972  [NCBI]

QKPLKRKTPGQLKVATCCEEAKELKAQIANLTSLLSELSKKQERDWVSVVMQVMELESSTKRMESRLTDAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETAGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRRPTRLRVEMEDWEGSVRYAEYSRFVLGNELNSYRLFLGNYSGNVGNDALLYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSSYSLRRVEMKIRPEDFQP

Approximately 35 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.