ANGPT2/Angiopoietin-2, Dog (HEK293, His)

ANGPT2/Angiopoietin-2, Dog, intricately modulates angiogenesis by binding to TEK/TIE2, competitively impacting ANGPT1 signaling. It induces TEK/TIE2 phosphorylation independently and, in the absence of VEGF, may lead to endothelial apoptosis, contributing to vascular regression. Collaborating with VEGF, ANGPT2 facilitates angiogenesis, promoting endothelial cell migration and proliferation. Additionally, ANGPT2 regulates lymphangiogenesis, emphasizing its comprehensive role in vascular dynamics within dog biology. Its interactions with TEK/TIE2 and ITGA5 highlight its multifaceted contribution to angiogenesis and vascular regulation. ANGPT2/Angiopoietin-2, Dog (HEK293, His) is the recombinant dog-derived ANGPT2/Angiopoietin-2, Dog, expressed by HEK293, with C-6*His labeled tag. The total length of ANGPT2/Angiopoietin-2, Dog (HEK293, His) is 477 a.a., with molecular weight of 57.2 kDa.

狗血管生成素 2 蛋白 (ANGPT2) 在与 TEK/TIE2 结合时发挥多方面的作用，竞争 ANGPT1 结合位点并有效调节 ANGPT1 信号传导。值得注意的是，即使在 ANGPT1 缺失的情况下，ANGPT2 也能够诱导 TEK/TIE2 酪氨酸磷酸化。其功能延伸至血管生成调节，在缺乏 VEGF 等血管生成诱导剂的情况下，ANGPT2 介导的细胞-基质接触松弛可能导致内皮细胞凋亡，从而导致血管退化。相反，ANGPT2 与 VEGF 协同作用，可以促进内皮细胞迁移和增殖，充当允许的血管生成信号。此外，ANGPT2 还参与淋巴管生成的调节。该蛋白与 TEK/TIE2 的相互作用（与 ANGPT1 竞争相同的结合位点）以及与 ITGA5 的相互作用强调了其在狗生物学背景下的血管生成和血管调节中的综合作用。

Dog

HEK293

C-6*His

A0A8J8 (Y19-F495)

607616  [NCBI]

YNNFRRSMDSIGRRQYQVQHGSCSYTFLLPETDNCRSPGSYVPNAVQRDAPLDYDDSVQRLQVLENIMENNTQWLIKLENYIQDNMKKEMVEMQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLDMEDKHIVQLRSIKEEKDQLQVLVSKQNSIIEELEKQLVTATVNNSVLQKQQHDLMETVHSLLTMISPSKSPKDTFVAKEEQIIYRDCAEVFKSGLTTNGIYTLTFPNSTEEIKAYCDMETSGGGWTVIQRREDGSVDFQRTWKEYKVGFGNPSGEHWLGNEFVFQVTNQQPYVLKIHLKDWEGNEAYSLYEHFYLSGEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDADNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKGTTMMIRPADF

57.2 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.