1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Angiopoietins
  4. ANG-2
  5. ANGPT2/Angiopoietin-2, Dog (HEK293, His)

ANGPT2/Angiopoietin-2, Dog (HEK293, His)

目录号: HY-P700396
产品使用指南

ANGPT2/Angiopoietin-2(狗)通过与 TEK/TIE2 结合来复杂地调节血管生成,竞争性地影响 ANGPT1 信号传导。它独立诱导 TEK/TIE2 磷酸化,并且在没有 VEGF 的情况下,可能导致内皮细胞凋亡,从而促进血管消退。ANGPT2 与 VEGF 协同作用,促进血管生成,促进内皮细胞迁移和增殖。此外,ANGPT2 调节淋巴管生成,强调其在狗生物学血管动力学中的综合作用。它与 TEK/TIE2 和 ITGA5 的相互作用凸显了它对血管生成和血管调节的多方面贡献。ANGPT2/Angiopoietin-2, Dog (HEK293, His) 是重组的 ANGPT2/Angiopoietin-2,由 HEK293 表达,带有 C-6*His 标签。ANGPT2/Angiopoietin-2, Dog (HEK293, His) 全长 477 个氨基酸,分子量为 57.2 kDa。

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描述

ANGPT2/Angiopoietin-2, Dog, intricately modulates angiogenesis by binding to TEK/TIE2, competitively impacting ANGPT1 signaling. It induces TEK/TIE2 phosphorylation independently and, in the absence of VEGF, may lead to endothelial apoptosis, contributing to vascular regression. Collaborating with VEGF, ANGPT2 facilitates angiogenesis, promoting endothelial cell migration and proliferation. Additionally, ANGPT2 regulates lymphangiogenesis, emphasizing its comprehensive role in vascular dynamics within dog biology. Its interactions with TEK/TIE2 and ITGA5 highlight its multifaceted contribution to angiogenesis and vascular regulation. ANGPT2/Angiopoietin-2, Dog (HEK293, His) is the recombinant dog-derived ANGPT2/Angiopoietin-2, Dog, expressed by HEK293, with C-6*His labeled tag. The total length of ANGPT2/Angiopoietin-2, Dog (HEK293, His) is 477 a.a., with molecular weight of 57.2 kDa.

研究背景

狗血管生成素 2 蛋白 (ANGPT2) 在与 TEK/TIE2 结合时发挥多方面的作用,竞争 ANGPT1 结合位点并有效调节 ANGPT1 信号传导。值得注意的是,即使在 ANGPT1 缺失的情况下,ANGPT2 也能够诱导 TEK/TIE2 酪氨酸磷酸化。其功能延伸至血管生成调节,在缺乏 VEGF 等血管生成诱导剂的情况下,ANGPT2 介导的细胞-基质接触松弛可能导致内皮细胞凋亡,从而导致血管退化。相反,ANGPT2 与 VEGF 协同作用,可以促进内皮细胞迁移和增殖,充当允许的血管生成信号。此外,ANGPT2 还参与淋巴管生成的调节。该蛋白与 TEK/TIE2 的相互作用(与 ANGPT1 竞争相同的结合位点)以及与 ITGA5 的相互作用强调了其在狗生物学背景下的血管生成和血管调节中的综合作用。

种属

Dog

表达系统

HEK293

标签

C-6*His

蛋白编号

A0A8J8 (Y19-F495)

基因 ID
蛋白结构
N-term
ANGPT2 (Y19-F495)
Accession # A0A8J8
6*His
C-term
同用名
angiopoietin 2; angiopoietin-2; Ang2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; ANG2; AGPT2;
氨基酸序列

YNNFRRSMDSIGRRQYQVQHGSCSYTFLLPETDNCRSPGSYVPNAVQRDAPLDYDDSVQRLQVLENIMENNTQWLIKLENYIQDNMKKEMVEMQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLDMEDKHIVQLRSIKEEKDQLQVLVSKQNSIIEELEKQLVTATVNNSVLQKQQHDLMETVHSLLTMISPSKSPKDTFVAKEEQIIYRDCAEVFKSGLTTNGIYTLTFPNSTEEIKAYCDMETSGGGWTVIQRREDGSVDFQRTWKEYKVGFGNPSGEHWLGNEFVFQVTNQQPYVLKIHLKDWEGNEAYSLYEHFYLSGEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDADNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKGTTMMIRPADF

分子量

57.2 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

ANGPT2/Angiopoietin-2, Dog (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
ANGPT2/Angiopoietin-2, Dog (HEK293, His)
目录号:
HY-P700396
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