ANGPTL4/Angiopoietin-related 4 蛋白, Cynomolgus (HEK293, His)

ANGPTL4/angiopoietin-related 4 protein plays a key role in regulating lipid metabolism by inactivating lipoprotein lipase (LPL) and controlling the clearance of triglycerides in the blood. Its effects extend to the regulation of glucose homeostasis and insulin sensitivity. ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by HEK293 , with N-His labeled tag. The total length of ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His) is 243 a.a., with molecular weight of 35-40 kDa.

ANGPTL4/血管生成素相关 4 蛋白通过介导脂蛋白脂肪酶 (LPL) 的失活，在脂质代谢的复杂调节中发挥关键作用，从而有助于控制血液中甘油三酯的清除。除了参与脂质代谢之外，ANGPTL4 还可能在调节葡萄糖稳态和胰岛素敏感性中发挥重要作用。此外，它通过阻碍增殖、迁移和小管形成对内皮细胞发挥抑制作用，最终减少血管渗漏。体外研究表明，ANGPTL4 在异源表达时会阻碍内皮细胞与细胞外基质 (ECM) 的粘附，抑制肌动蛋白细胞骨架的重组，并破坏肌动蛋白应力纤维和粘着斑的形成。此外，与未切割的蛋白相比，ANGPTL4 的切割形式在 LPL 失活中表现出更高的活性，进一步强调了其在脂质稳态和内皮细胞功能中的多方面作用。根据具体情况，ANGPTL4 还可能调节肿瘤相关的血管生成，强调其对不同生理过程的背景影响。

Cynomolgus

HEK293

N-His

XP_045236104.1 (R164-S406)

102135390  [NCBI]

35-40 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.