ANGPTL8/Angiopoietin-like 8 蛋白, Mouse (P. pastoris, His)

ANGPTL8, a blood lipid regulator, controls serum triglyceride levels and orchestrates metabolic transitions during fasting and refeeding. Its role involves directing fatty acid storage in adipose tissue during the fed state. Though its precise mechanism is not fully understood, ANGPTL8 has been suggested to promote ANGPTL3 cleavage, interacting with ANGPTL3 for regulatory functions in lipid metabolism. ANGPTL8/Angiopoietin-like 8 Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived ANGPTL8/Angiopoietin-like 8 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of ANGPTL8/Angiopoietin-like 8 Protein, Mouse (P. pastoris, His) is 183 a.a., with molecular weight of 22.5 kDa.

ANGPTL8被称为血脂调节剂，在控制血清甘油三酯水平方面发挥着关键作用。这种激素参与协调禁食和重新进食之间的代谢转变，促进进食状态下脂肪组织中脂肪酸的定向储存。虽然其精确机制尚未完全阐明，但根据一份报告，ANGPTL8 被认为可以促进 ANGPTL3 裂解，尽管另一项研究反驳了这一说法，指出 ANGPTL8 不是 ANGPTL3 裂解所必需的。值得注意的是，ANGPTL8 与 ANGPTL3 相互作用，进一步促进其在脂质代谢中的调节功能。

Mouse

P. pastoris

N-6*His

Q8R1L8 (V16-A198)

624219  [NCBI]

VRPAPVAPLGGPEPAQYEELTLLFHGALQLGQALNGVYRATEARLTEAGHSLGLYDRALEFLGTEVRQGQDATQELRTSLSEIQVEEDALHLRAEATARSLGEVARAQQALRDTVRRLQVQLRGAWLGQAHQEFETLKARADKQSHLLWALTGHVQRQQREMAEQQQWLRQIQQRLHTAALPA

27 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.