Animal-Free Annexin A5/ANXA5 蛋白, Human (His)

Annexin A5 (ANXA5) protein acts as an anticoagulant, indirectly inhibiting the thromboplastin-specific complex in the coagulation cascade. ANXA5 exists as a monomer and its role is not limited to coagulation regulation, but also has binding interactions involving ATRX and EIF5B, suggesting its involvement in a variety of cells. Animal-Free Annexin A5/ANXA5 Protein, Human (His) is the recombinant human-derived animal-FreeAnnexin A5/ANXA5 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free Annexin A5/ANXA5 Protein, Human (His) is 320 a.a., with molecular weight of ~36.75 kDa.

膜联蛋白 A5 (ANXA5) 蛋白具有抗凝剂的功能，是在凝血级联中至关重要的凝血活酶特异性复合物的间接抑制剂。在结构上，ANXA5 作为单体存在，其作用超出了凝血调节范围。它表现出与 ATRX 和 EIF5B 的结合相互作用，表明参与多种细胞过程。值得注意的是，ANXA5 与乙型肝炎病毒 (HBV) 相互作用，表明在病毒相互作用中具有潜在作用。ANXA5 的多方面属性强调了其在细胞调节中的重要性，为止血及其与 HBV 等病毒病原体相互作用的参与提供了潜在的见解。

Human

E. coli

C-His

P08758 (M1-D320)

308  [NCBI]

MAQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGEDD

Approximately 36.75 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.