Animal-Free IL-17F 蛋白, Mouse (His)

IL-17F Protein, a cytokine belonging to the IL-17 family, is produced using recombinant DNA technology without the use of animal-derived materials. It is involved in inflammatory responses and immune regulation. IL-17F Protein offers a safe and ethical alternative for research and therapeutic applications, addressing concerns related to animal-based production methods. Animal-Free IL-17F Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-17F protein, expressed by E. coli , with C-His labeled tag.

IL-17F 是一种细胞因子，在宿主防御细胞外细菌和真菌中发挥作用。它诱导中性粒细胞炎症，并激活和招募中性粒细胞到感染和炎症部位。IL-17F 还刺激粘膜上皮细胞产生抗菌蛋白，限制微生物通过上皮屏障进入。它通过 IL-17RC 同二聚体受体复合物发出信号，激活 TRAF6 和 NF-kappa-B 信号通路。IL-17F 还诱导 IL33 的转录激活，IL33 是一种参与肺部真菌过敏反应的细胞因子。它促进周围器官的交感神经支配，调节肠道微生物群的组成和免疫耐受。IL-17F 与 IL-17A 形成同二聚体和异二聚体，并与 IL17RA 和 IL17RC 受体形成复合物。

Measure by its ability to induce IL-6 secretion in 3T3 cells. The ED₅₀ for this effect is <100 ng/mL.

Mouse

E. coli

C-His

Q7TNI7-1 (R29-A161)

257630  [NCBI]

MRKNPKAGVPALQKAGNCPPLEDNTVRVDIRIFNQNQGISVPREFQNRSSSPWDYNITRDPHRFPSEIAEAQCRHSGCINAQGQEDSTMNSVAIQQEILVLRREPQGCSNSFRLEKMLLKVGCTCVKPIVHQAA

Approximately 15.82 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 20 mM sodium citrate, pH 4.5, trehalose.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.