APBA3 蛋白, Human (His)

APBA3 Protein, Human (rHuAPBA3, His; Amyloid beta A4 precursor protein-binding family A member 3; APBA3) is an approximately 20.0 kDa APBA3 protein fused to His-tag. APBA3 Protein, Human (His) is an adapter protein that belongs to the X11 family and is involved in signal transduction processes^[1].

APBA3 是 X11 蛋白家族的第三个成员，与阿尔茨海默病 β-淀粉样前体蛋白 (APP) 相互作用。该基因全长约 11 kb，由 10 个编码外显子和 1 个非翻译外显子组成。APBA3 通过辐射杂交定位到 19 号染色体。
APBA3 含有 PDZ (DHR) 结构域和 1 个 PID 结构域，并与阿尔茨海默病淀粉样前体蛋白相互作用。APBA3 在许多组织中广泛表达，但在大脑和睾丸中表达量较低^[1]。

Human

E. coli

C-6*His

O96018 (M1-L138)

9546  [NCBI]

MDFPTISRSPSGPPAMDLEGPRDILVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQELVQQFEALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGLLSAEAGRDDLLGLLHCEECPPSQTGPEEPLEPAPRLHHHHHH

Approximately 20.0 kDa

Greater than 80% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. H Tanahashi, et al. Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein. Neuroreport. 1999 Aug 20;10(12):2575-8.  [Content Brief]

  [2]. Toshiro Hara, et al. Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock. J Biol Chem  [Content Brief]