Apolipoprotein A-V/APOA5 蛋白, Mouse (His)

Apolipoprotein AV (APOA5) is primarily associated with HDL and VLDL, affecting triglyceride (TG) levels. APOA5 stimulates apo-CII lipoprotein lipase (LPL) TG hydrolysis and inhibits hepatic VLDL-TG production without affecting VLDL-apoB production. Apolipoprotein A-V/APOA5 Protein, Mouse (His) is the recombinant mouse-derived Apolipoprotein A-V/APOA5 protein, expressed by E. coli , with N-His labeled tag. The total length of Apolipoprotein A-V/APOA5 Protein, Mouse (His) is 348 a.a., with molecular weight of ~40.5 kDa.

载脂蛋白 AV (APOA5) 是一种次要载脂蛋白，主要与 HDL 相关，在较小程度上与 VLDL 相关，也可能与乳糜微粒相关。它在调节血浆甘油三酯 (TG) 水平方面发挥着至关重要的作用，可作为 apo-CII 脂蛋白脂肪酶 (LPL) TG 水解的有效刺激剂，并作为肝脏 VLDL-TG 生成速率的抑制剂，而不影响 VLDL-apoB 生成速度。APOA5 激活卵磷脂：胆固醇酰基转移酶 (LCAT) 的能力较差，并且不会增强巨噬细胞的胆固醇流出。此外，它还表现出与肝素的结合亲和力并与 GPIHBP1 相互作用。此外，APOA5 与 SORL1 相互作用，影响其内化和分类，要么进入溶酶体降解，要么进入跨高尔基体网络。

Mouse

E. coli

N-His

Q8C7G5 (R21-G368)

66113  [NCBI]

Approximately 40.5 kDa

Greater than 95% as determined by Tris-Bis PAGE.

溶液

Supplied as a 0.22 μm filtered solution of 20 mM Tris, 500 mM NaCl, 10% glycerol, 2 mM DTT, pH 8.5.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.