ASGR2/ASGPR2 蛋白, Human (HEK293, His)

ASGR2 mediates endocytosis of desialylated glycoproteins, recognizing galactose and N-acetylgalactosamine units. Ligand binding leads to internalization and sorting organelle transport, followed by receptor return to the cell membrane. The receptor is suggested to function as a dimer. ASGR2 also interacts with LASS2. ASGR2/ASGPR2 Protein, Human (HEK293, His) is the recombinant human-derived ASGR2 protein, expressed by HEK293 , with N-His labeled tag.

ASGR2 蛋白充当血浆糖蛋白内吞作用的介质，特别是那些复杂碳水化合物部分上的末端唾液酸残基已被去除的血浆糖蛋白。该受体表现出识别末端半乳糖和 N-乙酰半乳糖胺单元的能力。配体与受体结合后，所得复合物发生内化并被转运至分选细胞器，在那里受体和配体解离。随后，受体返回到细胞膜表面。这表明该受体的功能性配体结合单元至少是二聚体。此外，ASGR2 与 LASS2 相互作用。

Human

HEK293

N-His

P07307 (Q80-A311)

433  [NCBI]

37-42 kDa

Greater than 90% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.