B7-H2/ICOSLG 蛋白, Cynomolgus (HEK293, His)

The Angiopoietin-1 Protein is a secreted glycoprotein that is a key ligand in the vascular tyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells. B7-H2/ICOSLG Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Cynomolgus (HEK293, His) is 256 a.a., with molecular weight of 50-70 KDa.

血管生成素-1 (ANGPT1) 编码血管生成素家族中的一种分泌糖蛋白，是血管酪氨酸激酶信号通路的关键配体。ANGPT1 通过激活 PTK2/FAK 及下游激酶 MAPK1/ERK2、MAPK3/ERK1 信号通路刺激血管新生。Angiopoietin-1 Protein 调节血管的形成和稳定，在血管发育中有重要作用。ANGPT1 影响成骨骼肌细胞的增殖、迁移和分化。

Human ICOS, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus B7-H2, His Tag with an affinity constant of 5.42 nM as determined in SPR assay (Biacore T200).

Cynomolgus

HEK293

C-His

XP_005548617.1 (M1-T256)

102132485  [NCBI]

50-70 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.