2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens
  4. Stimulatory Immune Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins
  5. B7-H2/ICOSLG B7-H2/CD275
  6. B7-H2/ICOSLG 蛋白, Rat (HEK293, Fc)

B7-H2/ICOSLG 蛋白, Rat (HEK293, Fc)

目录号: HY-P75487
产品使用指南

B7-H2/ICOSLG 蛋白是 T 细胞受体 ICOS 的配体，可严重共刺激 T 细胞增殖和细胞因子分泌。它诱导 B 细胞增殖并支持浆细胞分化，在局部组织对炎症的反应中发挥关键作用。B7-H2/ICOSLG 还通过共同刺激记忆 T 细胞功能来调节二次免疫反应。在分子相互作用中，已观察到它在体外与 CTLA4 相互作用。B7-H2/ICOSLG 蛋白, Rat (HEK293, Fc) 是重组的 B7-H2/ICOSLG 蛋白，由 HEK293 表达，带有 C-hFc 标签。

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描述

B7-H2/ICOSLG Protein, a ligand for T-cell receptor ICOS, critically costimulates T-cell proliferation and cytokine secretion. It induces B-cell proliferation and supports plasma cell differentiation, playing a key role in local tissue responses to inflammation. B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function. In molecular interactions, it has been observed to interact with CTLA4 in vitro. B7-H2/ICOSLG Protein, Rat (HEK293, Fc) is the recombinant rat-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc labeled tag.
研究背景

B7-H2/ICOSLG 蛋白作为 T 细胞特异性细胞表面受体 ICOS 的配体，充当 T 细胞增殖和细胞因子分泌的关键共刺激信号。此外，它还能诱导 B 细胞增殖并促进其分化为浆细胞。这种蛋白质有望在介导局部组织对炎症反应的反应以及通过共同刺激记忆 T 细胞功能来调节二次免疫反应方面发挥重要作用。在分子相互作用中，B7-H2/ICOSLG 已被证明可以在体外与 CTLA4 相互作用。
种属

Rat
表达系统

HEK293
标签

C-hFc
蛋白编号

XP_006223893 (E25-K261)
基因 ID
蛋白结构
N-term
B7-H2 (E25-K261)
Accession # XP_006223893
hFc
C-term
同用名
ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275
分子量

Approximately 53.6 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

B7-H2/ICOSLG Protein, Rat (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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